Diagnosis of Polyneuropathies

etiology, significance, diagnosis and treatment of bruxiam

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Pathophysiology of autoimmune polyneuropathies.

The most common autoimmune neuropathies include the acute inflammatory polyneuropathy [the Guillain-Barré Syndrome(s)]; chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN) and IgM anti-MAG-antibody mediated paraproteinemic neuropathy. These neuropathies occur when immunologic tolerance to peripheral nerve components (myelin, Schwann cell, axon, and motor ...

Inherited polyneuropathies.

The large degree of clinical heterogeneity within each of the major categories of inherited neuropathies can lead to difficulties in making correct diagnoses based on clinical findings alone. The observation of key clinical findings coupled with electrophysiological findings and understanding of inheritance patterns, should allow the clinician to make judicious use of genetic testing to confirm...

Chemotherapy and Polyneuropathies

The evaluation of polyneuropathies.

P olyneuropathy has an estimated prevalence of 2%–3% in the general population and a prevalence as high as 8% in people over the age of 55 years.1 Roughly one-third of polyneuropathies will have a genetic cause, one-third an acquired etiology, and onethird will be idiopathic, despite appropriate diagnostic evaluation.2 There are over 100 known acquired and inherited disorders that may cause pol...